William H. Harris, MD, received OREF grants to study bone resorption (1960) and the capacity of growth hormones to reverse osteoporosis (1970), early research which led to the identification of osteolysis and subsequent ways to prevent it.

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Joseph M. Lane, MD, received OREF Research Grants in 1975 and 1978, which he used to study collagen structure and metabolism in fracture healing and endochondral ossification grafts for osseous defects.

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Roby C. Thompson, MD, received two OREF grants to research whether proteoglycan synthesis increases in osteoarthritic cartilage and how proteoglycan matrix is depleted, defining the early pathways of osteoarthritic destruction of the joint.

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Frederick Matsen III, MD, received three OREF grants to research intracompartmental tissue pressure. His research led to an understanding of clinical symptoms that allowed orthopaedic surgeons to assess limbs at risk for compartmental syndrome.

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Joseph A. Buckwalter IV, MD, received OREF grants to research the structure of hyaline cartilage proteoglycan aggregate and structural changes that may occur with aging and ways to enhance collagen synthesis following a ligament tear to shorten rehabilitation.

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Steven P. Arnozcky, DVM, received OREF funding to evaluate the structural, physiological, and biomechanical character of cryopreserved meniscal allografts transplanted into knee joints to learn if they could be used to replace a damaged or removed meniscus.

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